Secondary hyperparathyroidism. Secondary hyperparathyroidism of renal origin
Conditions
Interventions
Intervention 1: Intervention group A: Receiving Calcitriol 1 mg orally every other night. Intervention 2: Intervention group B: Receiving Calcitriol 1 mg orally every other night plus Cinacalcet 30 mg
Sponsors
Gorgan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Aged 18 years and more; Dialysis for at least 3 months; iPTH levels above 800 pg/dL (severe secondary hyperparathyroidism); Do not take medications that have drug interactions such as flecainide, thioridazine, tricyclic antidepressants due to the effect of Cinacalcet on the P-450 cytochrome; No hypersensitivity reaction to the drugs used in the study; No liver disease; Calcium levels > 8.4 mg/dL.
Exclusion criteria
Exclusion criteria: Any evidence of cancer in different parts of the body; Side effects of the medications used during the study period; Diseases causing hypercalcemia; History of parathyroidctomy; Presence of parathyroid adenoma (to be confirmed by parathyroid scan); Pregnant mothers or lactating women or females of childbearing age who do not currently use contraception.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decreased parathyroid hormone levels. Timepoint: Before study and 3 and 6 months after treatment. Method of measurement: Blood test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Decreased serum phosphorus and calcium levels. Timepoint: Before study and 3 and 6 months after treatment. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSedigheh Ebrahimi
Gorgan University of Medical Sciences
Outcome results
None listed