The effect of preoperative use of celecoxib , gabapentin , combination of celecoxib with gabapantin and combination of celecoxib with dexamethasone and gabapantin on postoperative pain relief

Evaluation and comparison of the effect of preoperative use of celecoxib , gabapentin , combination of celecoxib with gabapantin and combination of celecoxib with dexamethasone and gabapantin in reducing postoperative pain in patients undergoing total knee replacement surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200217046523N10

Enrollment

144

Registered

2021-02-04

Start date

2021-02-18

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total Knee Arthroplasty. Sarcoid arthropathy

Interventions

Intervention 1: Intervention group 1: Patients in this group are treated with two doses of 400 mg celecoxib alone before surgery and their pain will be assessed by analog visual criteria at 24, 48 and

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age over 18 years Candidate for unilateral TKA surgery due to primary osteoarthritis Satisfaction to participate in the study

Exclusion criteria

Exclusion criteria: Failure to follow up and examine the patient's condition Death of the patient Having chronic diseases

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: 24, 48 and 72 hours after surgery. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Motififard

Esfahan University of Medical Sciences

motififard@med.mui.ac.ir+98 31 3337 7986

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026