Vaginal atrophy. Postmenopausal atrophic vaginitis
Conditions
Interventions
Citrus aurantium vaginal cream 4%, one applicator every night for two weeks and then one night in between in later two-weeks.
Sponsors
Gonabad University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: Having amenorrhea for at least 12 months Age 45-65 years old Having sex with single spouse Normal Pap smear over the past 3 years Body mass index less than 30 Complaining of vaginal atrophy symptoms (vaginal burning, vaginal itching , Vaginal dryness and pain during intercourse) Getting a score of = 65 on the visual analogue scale (VAS) Having at least one symptom of vaginal mucosa descriptive evaluation table symptoms pH value > 5 Vaginal maturation value (VMV) < 50
Exclusion criteria
Exclusion criteria: Vaginal infection or any other important genital tract disease (sexually transmitted diseases) Excessive consumption of phytoestrogens such as soy, red clover, fenugreek and vitex during the 8 weeks prior to the study Use of hormone replacement therapy during the 8 weeks before the study A history of asthma and allergies to certain herbs or citrus fruits Use of vaginal drugs or any lubricant for at least 15 days prior to study Smoking, alcohol or any other drug Mammary mass Uterine bleeding or spotting Kidney Disorders, Kidney Failure, Hypertension, Thyroid Disorders, Liver Disorders, Heart Problems, Psychological problems and epilepsy Use of monoamine oxidase drugs, antidepressants, Antihypertensive drugs, thyroid medication, supplements and vitamins Prolapse of pelvic organs grade 3 or More
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vaginal acidity. Timepoint: Before and 2 and 4 weeks after intervention. Method of measurement: pH strip.;Vaginal maturation value. Timepoint: Before and 2 and 4 weeks after intervention. Method of measurement: Vaginal smear.;Subjective symptoms of vaginal atrophy. Timepoint: Before and 2 and 4 weeks after intervention. Method of measurement: Visual Analogue Scale.;Vaginal physical examination. Timepoint: Before and 2 and 4 weeks after intervention. Method of measurement: Vaginal physical examination checklist. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: Before and 2 and 4 weeks after intervention. Method of measurement: Menopause quality of life questionnaire (MENQOL questionare). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahram Asgharpoor
Gonabad University of Medical Sciences
Outcome results
None listed