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The effect ofmidazolam and anxiety on amnesia

The effects of different doses of midazolam and preoperative anxiety on retrograde and anterograde amnesia in patients undergoing abdominal laparotomy under general anesthesia

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200213046484N1
Enrollment
120
Registered
2020-03-06
Start date
2020-05-21
Completion date
Unknown
Last updated
2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

anxiety. Generalized anxiety disorder

Interventions

Intervention 1: Intervention group: : Midazolam .02mg / kg , One dose is injected as a premedication. Intervention 2: Intervention group: Midazolam .04mg / kg ,One dose is injected as a premedicat

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 120 patients aged 20 to 60 years at risk of ASA1-2 undergoing non-emergency abdominal laparotomy undergoing GA at Rasool Akram Hospital

Exclusion criteria

Exclusion criteria: Patients with ASAIII risk The Pregnant patient Patients with psychiatric disorders or receiving sedative and antipsychotic medications Mental dysfunction Patients with visual or hearing impairment Patients with liver and kidney dysfunction Previous use of benzodiazepine

Design outcomes

Primary

MeasureTime frame
Amnesia. Timepoint: Zero minutes (4 min before premedication), 2 (2 min before premedication), 4 (immediately before premedication) 6 min (2 min after premedication), 8 (4 min after Premedication) and 10 (6 min after premedication. Method of measurement: Cards with simple photos.

Secondary

MeasureTime frame
Blood pressure. Timepoint: minutes 1,2,3 after intubation. Method of measurement: NIBP.;Heart rate. Timepoint: Minutes 1,2,5after intubation. Method of measurement: Monitoring device.;Decrease in oxygen saturation. Timepoint: Minutes 1,2,5after intubation. Method of measurement: Pulse oximetry.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzadeh Habibi

Iran University of Medical Sciences

azade_h84@yahoo.com+98 21 6435 2326

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026