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The effectiveness of probiotics pills on microbial population in orthodontic patient

A clinical trial to compare the effectiveness of probiotics pills with fluoride mouthwash on microbial population in saliva in fixed orthodontic patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200203046363N1
Enrollment
75
Registered
2020-03-02
Start date
2020-04-20
Completion date
Unknown
Last updated
2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthodontic. Fitting and adjustment of ileostomy and other intestinal appliances

Interventions

Intervention 1: The intervention group will receive Lacto Gum biodegradable sucker pills containing Lactobacillus salivarius produced by Biology Fermentation Company for 3 weeks. Intervention 2: Contr

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
14 Years to 18 Years

Inclusion criteria

Inclusion criteria: Age of 17-18 years No history of systemic disease Nonuse of antibiotic and probiotic drugs The patient is in the middle of the spectrum regarding caries risk, and not high caries risk is recommended. In addition, the individual should have good oral hygiene

Exclusion criteria

Exclusion criteria: Dentinogenesis imperfect Amelogenesis imperfect Having specific metabolic diseases Bulimia nervosa Anorexia nervosa Having probiotics drug intolerance

Design outcomes

Primary

MeasureTime frame
Buffering power of the saliva. Timepoint: Before and 3 weeks after the intervention. Method of measurement: PH meter device.;Streptococcus mutans population. Timepoint: Before and 3 weeks after the intervention. Method of measurement: Microbial counting.;Lactobacillus population. Timepoint: Before and 3 weeks after the intervention. Method of measurement: Microbial counting.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirreza Faraji Eraghi

Mashhad University of Medical Sciences

farajiar931@mums.ac.ir+98 51 3884 1674

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026