topical tranexamic acid in perioperative blood loss of the posterior lumbar spinal surgery

Role of topical tranexamic acid in reducing perioperative blood loss in traumatic and non-traumatic patients undergoing posterior lumbar spinal surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200203046351N1

Enrollment

104

Registered

2020-12-16

Start date

2020-12-04

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: ???? ???? ???. Condition 2: ?????? ???? ??? ???? ???? ?????. Other intervertebral disc displacement, lumbar region Unspecified fracture of unspecified lumbar vertebra, initial encounter for closed fracture

Interventions

Intervention 1: Intervention group: solution of 3 gr TXA in 100 cc normal saline will use for intermittent washing and soaking sterile gases for packing. Intervention 2: Control group: Normal saline.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients with age between 18 to 75 years . Patients whom needs posterior lumbar spinal surgery Traumatic patients ( in the first 3 weeks after injury) Non-traumatic patients (with maximum 4 spinal level envolved)

Exclusion criteria

Exclusion criteria: History of thromboembolism Emergent surgery with indications other than neurosurgical indications Treatment with other drugs that affect blood coagulation such as sodium valproate Any transexamic acid intake before (eg polymenorrhea in women or in dentistry) Treatment with anticoagulants Treatment with antiplatelets Spinal penetrating injury Hemodynamical unstability History of epilepsy or seizure Liver malfunction Renal failure Abnormal results of laboratory coagulation tests Patient's reluctance

Design outcomes

Primary

Measure	Time frame
Intraoperative blood loss. Timepoint: At the end of the operation. Method of measurement: with use of standard anesthesia chart by ml.	—

Secondary

Measure	Time frame
Duration of hospitalization. Timepoint: Time of discharge. Method of measurement: Questionnaire.;Coagulation studies. Timepoint: At the beginning of the study and post op. Method of measurement: questionnaire.;Duration of returning to work. Timepoint: 2 month post op. Method of measurement: questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEslamian, Mohammad

Tehran University of Medical Sciences

md.eslamian@gmail.com+98 21 6659 6934

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026