Contrast induced nephropathy. Nephropathy induced by other drugs, medicaments and biological substances
Conditions
Interventions
Intervention 1: Intervention group: 3 consecutive oral doses of 30 mg crocina brand tablets. before and 24 and 48 hrs after PCI. of note is that since crocina tablets are 15 mg, each time the patient
Sponsors
Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Undergoing coronary or peripheral angiography with or without intervention Cr > 1.2 mg/dL and 30 <GFR < 60 mL/min Systolic pressure of greater than 90 mm Hg No contraindications to hydration or contrast agent
Exclusion criteria
Exclusion criteria: History of hypersensitivity to saffron End-stage renal disease on dialysis Acute renal failure Pregnancy or lactation Emergent coronary angiography, ST elevation myocardial infarction (STEMI), or cardiogenic shock Patient receiving N-acetylcysteine or sodium bicarbonate Platelets less than or equal to 100,000/mm3 Left Ventricular ejection fraction less than 30 History of Kidney transplant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BUN & Creatinin. Timepoint: Before intervention and 24 and 72 hrs after that. Method of measurement: blood urine nitrogen and creatinine lab test.;(NGAL)Neutrophilic Gelatinase Associated Lipocaline. Timepoint: before and 8 hrs after angiography. Method of measurement: urine sample collection in urine sample containers. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShima Esfandyari
Kermanshah University of Medical Sciences
Outcome results
None listed