The effect of different genotypes of adiponectin gene on diabetes response to exercise

Survey on the synergistic effect of some adiponectin gene polymorphisms in response to aerobic training with two different intensities in middle-aged men with type 2 diabetes

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200201046326N1

Enrollment

300

Registered

2020-07-03

Start date

2019-08-22

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes. Type 2 diabetes mellitus

Interventions

Intervention 1: Intervention group 1: In this group, 50 diabetic patients perform low intensity aerobic exercise (65% of maximal oxygen consumption) for 12 weeks, 3 sessions per week. The content of a

Eligibility

Sex/Gender

Male

Age

45 Years to 65 Years

Inclusion criteria

Inclusion criteria: All diabetic patients who have more than 12 years history of diabetes Hemoglobin A1c above 7 Age under 65 years old

Exclusion criteria

Exclusion criteria: People with a history of cardiovascular disease and cancer Diabetic foot ulcer Having an amputation Severe retinopathy Having neurological and orthopedic disorders Having regular physical activity for the past 6 months

Design outcomes

Primary

Measure	Time frame
Adiponectin. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Adiponectin ELISA kit.;Five polymorphisms of the adiponectin gene. Timepoint: Before 12 weeks of aerobic exercise. Method of measurement: DNA extraction and pcr method.	—

Secondary

Measure	Time frame
Hemoglobin A1c. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Using the HbA1c kit and the enzyme method (Diazyme).;Fasting blood sugar. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Quantitative diagnostic kit (glucose oxidase), by enzymatic photometric method.;Low-density lipoprotein(LDL). Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Relevant diagnostic kit, Enzymatic method.;High-density lipoprotein (HDL). Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Relevant diagnostic kit, Enzymatic method.;Total Cholesterol. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Relevant diagnostic kit, Enzymatic method.;Triglycerides. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Relevant diagnostic kit, Enzymatic method.;Blood pressure. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Using a mercury sphygmomanometer.	—

Measure

Time frame

Hemoglobin A1c. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Using the HbA1c kit and the enzyme method (Diazyme).;Fasting blood sugar. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Quantitative diagnostic kit (glucose oxidase), by enzymatic photometric method.;Low-density lipoprotein(LDL). Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Relevant diagnostic kit, Enzymatic method.;High-density lipoprotein (HDL). Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Relevant diagnostic kit, Enzymatic method.;Total Cholesterol. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Relevant diagnostic kit, Enzymatic method.;Triglycerides. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Relevant diagnostic kit, Enzymatic method.;Blood pressure. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Using a mercury sphygmomanometer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactElahe Mamashli

The University of Mohaghgegh Ardabili

mamashli.elahe@gmail.com+98 17 3522 9933

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 15, 2026