Comparison of the effects of phenobarbital and levetiracetam on neonatal seizure after discharge

Comparison of the outcomes of neonatal seizure treatment with phenobarbital versus levetiracetam after discharge

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200131046317N3

Enrollment

Registered

2021-08-25

Start date

2021-09-01

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

convulsion of newborn. Convulsions of newborn

Interventions

Intervention 1: Intervention group: Patients in this group are treated with 30 mg/kg levetiracetam daily after discharge and are followed for recurrence of seizures, complications and neonatal develo

Eligibility

Sex/Gender

All

Age

1 Days to 1 Months

Inclusion criteria

Inclusion criteria: The age when seizures started is less than one month History of at least one seizure with an unknown cause Need for treatment at the time of discharge based on history, type of seizure and EEG

Exclusion criteria

Exclusion criteria: Finding any errors of metabolism as the cause of seizures Gestational age is below 36 weeks Congenital metabolic disorders Finding any structural abnormalities in the brain on magnetic resonance imaging of the brain or head ultrasound

Design outcomes

Primary

Measure	Time frame
Reoccurrence of seizures. Timepoint: 3 and 6 months after discharge. Method of measurement: Based on parents' reports.;The newborn's growth. Timepoint: 3 and 6 months after discharge. Method of measurement: Clinical observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNazanin Saeidi Zand

Mashhad University of Medical Sciences

dr.nazanin_zand@yahoo.com+98 51 3801 2496

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026