Evaluation of the Efficacy of Combined Topical Gel of Verapamil, Nitroglycerin and Lidocain in Prevention of Radial Artery Spasm Incidence

Evaluation of the Efficacy of Combined Topical Gel of Verapamil, Nitroglycerin and Lidocain in Prevention of Radial Artery Spasm During Transradial Angiogplasty

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200128046296N1

Enrollment

128

Registered

2020-03-21

Start date

2020-04-04

Completion date

Unknown

Last updated

2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Coronary Syndrome. Angina pectoris

Interventions

Intervention 1: Intervention group: 1 gram of therapeutic gel is applied to the wrist overlying radial pulse (centered approximately 1 cm proximal to the radial styloid process) at least half an hour

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age: 18 years or older Elective radial PCI candidates

Exclusion criteria

Exclusion criteria: Hypersensitivity or contraindication to lidocaine Hypersensitivity or contraindication to nitroglycerin Baseline weak radial pulse Inadequate blood supply to palm Presence of arteriovenous fistula for dialysis Pregnant women or nursing mothers

Design outcomes

Primary

Measure	Time frame
Radial artery diameter. Timepoint: Before gel application and just after. Method of measurement: Radial artery ultrasound.;Radial artery spasm. Timepoint: During angioplasty. Method of measurement: Radial artery spasm score: A) Verbal or nonverbal expression of discomfort in the forearm during catheter/sheath manipulation: Absent: 0; Present: 1; B) Difficulty in manipulating the catheter: Absent: 0; Present: 1; C) Difficulty in sheath removal: Absent: 0; Present: 1; D) Additional use of intraarterial nitroglycerine or verapamil after the initial vasodilator cocktail for suspected radial artery spasm: No: 0; Yes: 1. Incidence of radial artery spasm indicated by a Radial artery spasm score of 1 or more.;Patient pain. Timepoint: After sheath insertion during angioplasty. Method of measurement: Visual analoug scale and verbal scale of pain.;Sympathetic system response. Timepoint: Before angioplasty and then after. Method of measurement: Measuring of systolic blood pressure, diastolic blood pressure and heart rate.	—

Measure

Time frame

Radial artery diameter. Timepoint: Before gel application and just after. Method of measurement: Radial artery ultrasound.;Radial artery spasm. Timepoint: During angioplasty. Method of measurement: Radial artery spasm score: A) Verbal or nonverbal expression of discomfort in the forearm during catheter/sheath manipulation: Absent: 0; Present: 1; B) Difficulty in manipulating the catheter: Absent: 0; Present: 1; C) Difficulty in sheath removal: Absent: 0; Present: 1; D) Additional use of intraarterial nitroglycerine or verapamil after the initial vasodilator cocktail for suspected radial artery spasm: No: 0; Yes: 1. Incidence of radial artery spasm indicated by a Radial artery spasm score of 1 or more.;Patient pain. Timepoint: After sheath insertion during angioplasty. Method of measurement: Visual analoug scale and verbal scale of pain.;Sympathetic system response. Timepoint: Before angioplasty and then after. Method of measurement: Measuring of systolic blood pressure, diastolic blood pressure and heart rate.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzita Hajhossein Talasaz

Tehran University of Medical Sciences

atalasaz@razi.tums.ac.ir+98 21 6658 1692

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026