Investigating the effect of fibroblasts cultured with exosomes on acne scars

Investigating the effectiveness of fibroblast cultured with exosome compared to fibroblast in scars caused by facial acne: a double-blind randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200127046282N63

Enrollment

Registered

2025-12-17

Start date

2025-12-21

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrophic scar. Scar conditions and fibrosis of skin

Interventions

Intervention 1: Intervention group: Patients will receive fractional CO2 laser resurfacing on one half of their face along with an injection of cultured fibroblasts with exosome. They will also underg

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Acne scar grade 2 to 3 skin

Exclusion criteria

Exclusion criteria: Under 18 years old Having malignancy or a history of receiving chemotherapy Breastfeeding or pregnancy Family history of bleeding or coagulant diseases Taking anticoagulant medications or steroids Hemoglobin less than 10 and platelet count less than 150

Design outcomes

Primary

Measure	Time frame
Scar size. Timepoint: before and 3 month after the intervention. Method of measurement: Visio face.	—

Secondary

Measure	Time frame
Side effects. Timepoint: One week after treatment. Method of measurement: Questionnaire and visit.;Patient Satisfaction. Timepoint: Three month after treatment. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSona Zare

Skin and Stem cell Research Center of Tehran University of Medical Sciences

dr.sonazare@gmail.com+98 21 2665 7438

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026