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Investigating the combination of microfat, PRF, and exosomes for rejuvenation

clinical trial evaluation of therapeutic efficacy of microfat injection in combination with PRF(plasma rich fibrin) and Fibroblast-derived exosomes each alone and the combination of microfat and PRF and exosome compared to the basic treatment of microfat injection for rejuvenation of the nasolabial region; clinical trial

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200127046282N61
Enrollment
30
Registered
2025-12-02
Start date
2025-12-21
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin aging. Atrophic disorder of skin

Interventions

Intervention 1: Control group: Patients undergo a single session of microfat ??treatment on one side of the face and a combined microfat ??and PRF treatment on the other side of the face. Intervention

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients over 18 Patients who are not satisfied with their nasolabial folds

Exclusion criteria

Exclusion criteria: Pregnant people Breastfeeding people People under 18 and over 65 People who have undergone another intervention in the last 6 months before the injection (hyaluronic acid injection, fat injection, PRP injection, etc.) People with coagulation disorders or taking anticoagulant medications

Design outcomes

Primary

MeasureTime frame
The amount of wrinkles. Timepoint: Before treatment, one and six months after the start of treatment. Method of measurement: Visio face.

Secondary

MeasureTime frame
Inflammation. Timepoint: After injection. Method of measurement: Questionnaire and visit.;Intensity of pain. Timepoint: Treatment time. Method of measurement: Questionnaire and visit.;Side effects. Timepoint: One week after treatment. Method of measurement: Questionnaire and visit.;Patient Satisfaction. Timepoint: One and six months after treatment. Method of measurement: Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSona Zare

Skin and Stem cell Research Center of Tehran University of Medical Sciences

dr.sonazare@gmail.com+98 21 2665 7438

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026