Studying the effect of combined CO2 laser and PRP-conditioned medium method in the treatment of resistant atopic eczema

Safety and efficacy of combined CO2 laser and PRP-conditioned medium derived from Wharton's jelly stem cells in the treatment of refractory atopic eczema compared to PRP-CM injection alone

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200127046282N57

Enrollment

Registered

2025-11-20

Start date

2025-11-21

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hand eczema. Diseases of the skin and subcutaneous tissue

Interventions

Intervention 1: Intervention group: In the intervention plaque, the treated area undergoes a combination of CO2 laser and PRP - Wharton's jelly stem cells conditioned medium in 3 sessions, one month a

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Patients with multi-plaque atopic eczema Age 18 years and above and less than 40 years Complete patient consent to participate in the project.

Exclusion criteria

Exclusion criteria: Patients with malignancy Receiving chemotherapy within the last 5 years Patients with sepsis Smoking Pregnancy or breastfeeding Active wound or infection at the treatment site Receiving any topical or systemic medication for eczema in the last 2 months

Design outcomes

Primary

Measure	Time frame
Reduce or improve hand eczema. Timepoint: before and two weeks after the end of the study. Method of measurement: Using Eczema Extent and Severity Scale (EASI).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSona Zare

Skin and Stem cell Research Center of Tehran University of Medical Sciences

sonazarebio@gmail.com+98 21 2665 7438

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026