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Investigation of fractional CO2 laser and adipose tissue exosome in the treatment of acne scars and skin rejuvenation

Investigation of the safety and effectiveness of the combined treatment of fractional CO2 laser and exosome derived from adipose tissue mesenchymal stem cells in the treatment of acne scars and skin rejuvenation compared to fractional CO2 laser alone: ??a randomized, single-blind clinical trial

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200127046282N52
Enrollment
16
Registered
2024-08-15
Start date
2024-08-21
Completion date
Unknown
Last updated
2024-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Skin aging. Condition 2: Atrophic scar. Atrophic disorder of skin Scar conditions and fibrosis of skin

Interventions

Intervention 1: Intervention group: (one side of the face) after sufficient anesthesia, it is treated with CO2 laser and exosome injection (Zist Sakht Bonyan Pars Company, Sharif University of Technol

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: A patient with moderate and severe acne scars Complete consent of the patient to participate in the plan.

Exclusion criteria

Exclusion criteria: malignancy Receiving chemotherapy in the last 5 years Sepsis Smoking Pregnancy or breastfeeding Active wound or infection at the treatment site Receiving any topical or systemic medication in the last 3 months for acne scars

Design outcomes

Primary

MeasureTime frame
The amount of wrinkles. Timepoint: Before treatment and six months after the start of treatment. Method of measurement: Visio face.;Scar size. Timepoint: Before treatment and six months after the start of treatment. Method of measurement: Visio face.

Secondary

MeasureTime frame
Inflammation. Timepoint: After each session. Method of measurement: Questionnaire and visit.;Intensity of pain. Timepoint: Treatment time. Method of measurement: Questionnaire and visit.;Side effects. Timepoint: One week after treatment. Method of measurement: Questionnaire and visit.;Patient Satisfaction. Timepoint: Three month after treatment. Method of measurement: Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSona Zare

Skin and Stem cell Research Center of Tehran University of Medical Sciences

sonazarebio@gmail.com+98 21 2665 7438

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026