Investigating the combination of platelet-rich plasma and fat-derived stem cells in dark circles around the eyes

A comparative study of the effectiveness and side effects of using a combination of platelet-rich plasma and adipose-derived stem cells with platelet-rich plasma treatment alone in dark circles around the eyes.

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200127046282N49

Enrollment

Registered

2024-07-10

Start date

2024-07-10

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periorbital dark circles. Chloasma of eyelid and periocular area

Interventions

Intervention 1: Intervention group: In each session, patients are treated by injecting half a cc of conditioned medium derived from adipose tissue cells and half a cc of PRP, twice with an interval of

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age from 18 to 65 years Patient with periorbital dark circles

Exclusion criteria

Exclusion criteria: Active infection on face Pregnancy Breastfeeding History of cancer Structural dark circles or under eye loss of fat

Design outcomes

Primary

Measure	Time frame
Periorbital dark circles. Timepoint: Before and 1 months after treatment. Method of measurement: severity of under eye dark halos in comparison to the rest of the face, using mexameter device.	—

Secondary

Measure	Time frame
Satisfaction rate. Timepoint: 1 month after the last meeting. Method of measurement: Comparing the severity of periorbital dark circles, before and after treatment (score from 0 - 10).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSona Zare

Skin and Stem cell Research Center of Tehran University of Medical Sciences

sonazarebio@gmail.com+98 21 2665 7438

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026