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Comparison of the treatment of dark circles around the eyes by platelet-rich plasma-conditioned medium with Q-Switched laser

Comparing the safety and effectiveness of the treatment of dark circles around the eyes by platelet-rich plasma-conditioned medium derived from Wharton jelly mesenchymal stem cells with Q-Switched laser: a randomized clinical trial study.

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200127046282N40
Enrollment
10
Registered
2024-06-08
Start date
2024-06-14
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periorbital dark circles. Chloasma of eyelid and periocular area

Interventions

Intervention 1: Intervention group: patients are treated with Q-switched Nd:YAG 1064nm laser, 0.5 cc conditioned medium injection and 0.5cc PRP injection three times with four weeks interval. Interven

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age from 18 to 65 years Patient with periorbital dark circles

Exclusion criteria

Exclusion criteria: Active infection on face Pregnancy Breastfeeding History of cancer Structural dark circles or under eye loss of fat

Design outcomes

Primary

MeasureTime frame
Periorbital dark circles. Timepoint: Before and 3 months after treatment. Method of measurement: severity of under eye dark halos in comparison to the rest of the face, using mexameter device.

Secondary

MeasureTime frame
Satisfaction rate. Timepoint: Three months after the last meeting. Method of measurement: comparing the severity of periorbital dark circles, before and after treatment (score from 0 - 10).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSona Zare

Skin and Stem cell Research Center of Tehran University of Medical Sciences

sonazarebio@gmail.com+98 21 2665 7438

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026