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Investigating the effectiveness of CO2 fractional laser and conditioned medium in the treatment of burn scars

Investigating the effectiveness of the combination therapy of CO2 fractional laser and conditioned medium derived from foreskin fibroblast cells in the treatment of burn scars compared to CO2 fractional laser alone : Phase 1 clinical trial

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200127046282N33
Enrollment
18
Registered
2024-05-16
Start date
2024-05-30
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

burn scar. Atrophic disorders of skin

Interventions

Intervention 1: Patients with the deka fractional CO2 laser, along with 2 cc of fibroblast cell conditioning medium, will receive three sessions one month apart. Intervention 2: Control group: Patient

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Patients with skin type 1-4 Patients with atrophic burn scars in more than one organ from 5 years ago to 3 months ago

Exclusion criteria

Exclusion criteria: Age under 18 years Patients who have received laser treatment in the last three months Patients with active colloidal scar or active skin lesion at the injection site Patients with coagulation and platelet disorders Patients with a history of underlying disease such as diabetes and autoimmune connective tissue disease that affect wound healing Patients with active viral infections Patients with a history of anticoagulants History of malignancy or receiving chemotherapy Pregnancy and lactation

Design outcomes

Primary

MeasureTime frame
Scar size. Timepoint: before and 6 month after the intervention. Method of measurement: visioface.

Secondary

MeasureTime frame
Side effects. Timepoint: One week after treatment. Method of measurement: Questionnaire and visit.;Patient Satisfaction. Timepoint: six months after treatment. Method of measurement: Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSona Zare

Tehran University of Medical Sciences

sonazarebio@gmail.com+98 21 2665 7438

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026