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Investigating the effectiveness of conditioned medium with IPL laser compared to extracellular vesicles with IPL laser in the treatment of rosacea

Investigating the effectiveness of conditioning medium derived from Wharton's jelly tissue along with IPL laser Compared with Wharton jelly tissue-derived extracellular vesicles conditioned with IPL laser In the treatment of rosacea

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200127046282N32
Enrollment
30
Registered
2024-05-13
Start date
2023-05-20
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rosacea. Rosacea

Interventions

Intervention 1: Intervention group: After performing the IPL laser, the patients are subjected to the local spray of 5 cc human Wharton's jelly mesenchymal stem cell conditioned medium (Produced by Zi

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Suffering from rosacea Not receiving other treatments in the last three months Eligible men and women from 18 to 60 years with severe erythema rosacea based on a patient self-assessment (PSA) score of 4 (severe) and a physician evaluation of erythema (CEA) score of 3 or more have the ability to enter the study

Exclusion criteria

Exclusion criteria: causing severe drug side effects Those who had more than 5 inflammatory lesions on the face (pointy acne or purulent acne) Specific forms of rosacea (rosacea conglobata, rosacea fulminans, isolated rhinophyma, isolated pastilosis of the chin) They had other facial dermatitis similar to rosacea (such as perioral dermatitis), dimadisidosis, keratinization, seborrheic dermatitis, acute lupus erythematosus, or actinic telangiectasian.

Design outcomes

Primary

MeasureTime frame
Severity of rosacea lesions based on physician assessment (CEA). Timepoint: Before treatment and 4 and 8 weeks after. Method of measurement: Physical examination.

Secondary

MeasureTime frame
Severity of rosacea lesions based on patient self-assessment (PSA). Timepoint: Before treatment and 4 and 8 weeks after. Method of measurement: Questionnaire PSA (patient's self-assessment) (evaluating the severity of erythema and redness from the patient's perspective).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSona Zare

Skin and Stem cell Research Center of Tehran University of Medical Sciences

sonazarebio@gmail.com+98 21 2665 7438

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026