Effect of nanofat injection alone and combined with SVF, PRP and ND-YAG laser on treatment of periorbital dark circles and rejuvenation

Comparison of therapeutic effect of nanofat injection alone and nanofat with Stromal Vascular Fraction (SVF), Platelet Rich Plasma (PRP) and ND-YAG laser in improving darkening and rejuvenation under the eye

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200127046282N21

Enrollment

Registered

2023-01-22

Start date

2022-07-06

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

?Darkening under the eye. disorder of pigmentation, unspecified

Interventions

Intervention 1: 1 cc of nanofat with 1 cc of vascular stromal cells (SVF) extracted from adipose tissue will be injected in 2 sessions with an interval of 1 month. Intervention 2: Second intervention

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Under eye wrinkles, dark circles and need for rejuvenation based on dermatologist's diagnosis No medical treatment for under eye's dark circles, wrinkles and rejuvenation in recent 2 months Patients' Informed consent Ages under 50 and over 18 years

Exclusion criteria

Exclusion criteria: Skin lesions and diseases such as skin cancer Wart Skin infection Collagen and vascular diseases Pregnancy and lactation Taking steroids or anti-immune drugs

Design outcomes

Primary

Measure	Time frame
Darkness under the eyes. Timepoint: prior to treatment, three and six months after the last treatment session. Method of measurement: VisioFace device.;Under eye rejuvenation. Timepoint: prior to treatment, three and six months after the last treatment session. Method of measurement: Visioface.;Safety of treatment method. Timepoint: in the Injection session and one week after each session. Method of measurement: Questionnaire and clinical observation.	—

Measure

Time frame

Darkness under the eyes. Timepoint: prior to treatment, three and six months after the last treatment session. Method of measurement: VisioFace device.;Under eye rejuvenation. Timepoint: prior to treatment, three and six months after the last treatment session. Method of measurement: Visioface.;Safety of treatment method. Timepoint: in the Injection session and one week after each session. Method of measurement: Questionnaire and clinical observation.

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Secondary

Measure	Time frame
Pain Intensity. Timepoint: Injection session. Method of measurement: Questionnaire (scoring from 1 to 10) and visual pain questionnaire.;Patient satisfaction. Timepoint: prior to treatment, three months and six months after the last treatment session. Method of measurement: Standard questionnaires visual analogue scale (VAS).;Inflammation. Timepoint: 1-5 hours after injection. Method of measurement: In this study,?the inflammation rate around the eyes (with scores of 0 and 1), will be performed by a physician.	—

Measure

Time frame

Pain Intensity. Timepoint: Injection session. Method of measurement: Questionnaire (scoring from 1 to 10) and visual pain questionnaire.;Patient satisfaction. Timepoint: prior to treatment, three months and six months after the last treatment session. Method of measurement: Standard questionnaires visual analogue scale (VAS).;Inflammation. Timepoint: 1-5 hours after injection. Method of measurement: In this study,?the inflammation rate around the eyes (with scores of 0 and 1), will be performed by a physician.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSona Zare

Skin and Stem Cell Research Center, Tehran University of Medical Sciences

sonazarebio@gmail.com+98 21 2665 7438

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026