Lumbar disc herniation. Thoracic, thoracolumbar, and lumbosacral intervertebral disc disorders
Conditions
Interventions
Intervention 1: Intervention group: After surgical incision a spinal cord fluid sample of 1 cc is taken from the site of surgery, the needle stays in place and the syringe is removed and with another
Sponsors
Vice chancellor for research, Shahid Beheshti University of Medical Sciences , Loghman Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: No history of taking anti-inflammatory drugs two weeks before surgery Lack of AIDS and immunosuppressive diseases
Exclusion criteria
Exclusion criteria: GCS reduction for a reason other than stroke Change in the type of surgery according to the surgeon's opinion History of systemic diseases such as diabetes mellitus, renal failure and chronic pulmonary heart disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The level of Bax / Bcl-2¬ apoptotic factor in cerebrospinal fluid in dexmedetomidine and placebo group. Timepoint: After surgery and at the end of surgery. Method of measurement: Study of cerebrospinal fluid in dexmedetomidine and placebo group by ELISA.;Numering Rating Scale (NRS) Pain score in dexmedetomidine and placebo group. Timepoint: Before anesthesia and in recovery. Method of measurement: NRS scoring system.;The level of caspase-3 apoptotic factor in cerebrospinal fluid in dexmedetomidine and placebo group. Timepoint: After surgery and at the end of surgery. Method of measurement: Study of cerebrospinal fluid in dexmedetomidine and placebo group by ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Sam Hosseininasab
Shahid Beheshti University of Medical Sciences
Outcome results
None listed