The Comparative evaluation of effect of Sublingual Misoprostol versus cervical misoprostol on second Trimester abortions

The comparative evaluation of the effect of sublingual misoprostol versus wet cervical misoprostol on duration of abortion in patients candidates for abortion in early second Trimester

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200127046280N2

Enrollment

200

Registered

2020-10-17

Start date

2020-10-22

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abortion. Missed abortion

Interventions

Intervention 1: First intervention group (group a): This group will receive 200 mcg of sublingual misoprostol from the brand (Cytotec, Searle, England) along with cervical placebo(alborz daroo company

Eligibility

Sex/Gender

Female

Age

16 Years to 45 Years

Inclusion criteria

Inclusion criteria: Unifetal pregnancy Missed abortion Fetal malformations Blighted ovum Trisomies Gestational age ( 12 weeks and less than 12 weeks )

Exclusion criteria

Exclusion criteria: Rupture of membrane History of cesarean section more than once History of allergy to misoprostol and prostaglandins Contraindications of prostaglandin use ( like heart disease, kidney disease, history of seizures and hypotension )

Design outcomes

Primary

Measure	Time frame
The time interval between induction of abortion and excretion of pregnancy products. Timepoint: After intervention and then every one hour. Method of measurement: clock.;Nausea (drug side effects). Timepoint: After intervention and then every one hour. Method of measurement: Clinical examination and questioning of the patient.;Vomiting (drug side effects). Timepoint: After intervention and then every one hour. Method of measurement: Clinical examination and questioning of the patient.;Fever (drug side effects). Timepoint: After intervention and then every one hour. Method of measurement: Thermometer.;Diarrhea (drug side effects). Timepoint: After intervention and then every one hour. Method of measurement: Clinical examination and questioning of the patient.;Headache (drug side effects). Timepoint: After intervention and then every one hour. Method of measurement: Clinical examination and questioning of the patient.;Abortion type (Complete or incomplete). Timepoint: After intervention and then every one hour. Method of measurement: Clinical examination with speculum and doing ultrasonography.	—

Measure

Time frame

The time interval between induction of abortion and excretion of pregnancy products. Timepoint: After intervention and then every one hour. Method of measurement: clock.;Nausea (drug side effects). Timepoint: After intervention and then every one hour. Method of measurement: Clinical examination and questioning of the patient.;Vomiting (drug side effects). Timepoint: After intervention and then every one hour. Method of measurement: Clinical examination and questioning of the patient.;Fever (drug side effects). Timepoint: After intervention and then every one hour. Method of measurement: Thermometer.;Diarrhea (drug side effects). Timepoint: After intervention and then every one hour. Method of measurement: Clinical examination and questioning of the patient.;Headache (drug side effects). Timepoint: After intervention and then every one hour. Method of measurement: Clinical examination and questioning of the patient.;Abortion type (Complete or incomplete). Timepoint: After intervention and then every one hour. Method of measurement: Clinical examination with speculum and doing ultrasonography.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoumeh Dadashaliha

Qazvin University of Medical Sciences

dadashaliham@yahoo.com+98 28 3322 9304

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026