Ventricular septal Defect. Ventricular septal defect
Conditions
Interventions
Intervention 1: Intervention group: Children referred to physicians who had inadequate vitamin D levels and underwent non-emergency surgery for ventricular septal defect repair were given 400 internat
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Months to 6 Years
Inclusion criteria
Inclusion criteria: Patient undergo open heart surgery using a heart pump and pulmonary pump Age range from one month to six years Parents of children have informed consent to study
Exclusion criteria
Exclusion criteria: Patient's parents' unwillingness to participate in the study Complex heart disease Emergency surgery Multi-stage surgery Died during the intervention Children with abnormal blood albumin or PTH levels will be excluded.Children who take vitamin D concomitantly with corticosteroid drugs such as prednisolone, anticonvulsants such as phenobarbital and phenytoin, and tuberculosis drugs such as rifampin and isoniazid with various mechanisms including decreased calcium absorption, decreased vitamin D absorption, increased metabolism of vitamin D and vitamin D Reduces the effect of vitamin D. Therefore, they need to increase their vitamin D intake Children with a positive family history of kidney stones that are inherently higher in vitamin D will be excluded from the study Children who use anesthetic drugs that interfere with vitamin D levels during cardiopulmonary bypass will be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum vitamin D levels in children. Timepoint: Baseline, before surgical incision, 24 hours after surgery. Method of measurement: HPLC method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality rate. Timepoint: After surgery. Method of measurement: Follow-up until discharge.;Inotrop Score. Timepoint: when detached from Cardiopulmonary Machine, Highest in the first 24 ICU admissions. Method of measurement: Inotrope Score (IS) = Dopamine dose (mcg/kg/min) + Dobutamine dose (mcg/kg/min) + 100 x Epinephrine dose (mcg/kg/min).;Intubation Time. Timepoint: After surgery. Method of measurement: The patient's intubation hours after surgery.;Length of stay in intensive care unit. Timepoint: After surgery. Method of measurement: Days in the intensive care unit after surgery.;Duration of hospitalization. Timepoint: From patient admission to discharge. Method of measurement: Number of hospital days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Mansour Shafaat
Esfahan University of Medical Sciences
Outcome results
None listed