Effect of Metformin Combination with Double Antibiotic Paste (DAP) in Tooth Pulp Regeneration

Comparison of the Effect of Double Antibiotic Paste Alone or in Combination with Metformin on Regeneration of Non-Vital Immature Teeth: A Pilot Clinical Study

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200120046197N1

Enrollment

Registered

2021-02-26

Start date

2021-01-20

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth Pulp Necrosis. -

Interventions

Intervention 1: Control group: the tooth is anesthetized, isolated, and accessed. After determining the working length, the canals should be copiously irrigated with NAOCL 1.5%followed by 17% EDTA. Ca

Eligibility

Sex/Gender

All

Age

7 Years to 11 Years

Inclusion criteria

Inclusion criteria: Non- Vital Permanent Teeth with Open Apex(File size equal or more than 60) With or without Radiographic Radiolucency Negative Response to Pulp Vitality Test Restorable Tooth No Systemic Conditions

Exclusion criteria

Exclusion criteria: Severe periodontal disease, Internal and external root resorption

Design outcomes

Primary

Measure	Time frame
Pulp revitalization. Timepoint: Before intervention and patient follow up for 3 and 12 months after intervention. Method of measurement: Clinical And Radiographic Assessment.;Changes in diameter of root dentin with the regenerated tissues. Timepoint: Before intervention and patient follow up for 3 and 12 months after intervention. Method of measurement: Clinical And Radiographic Assessment.;Changes the length of root with the regenerated tissues. Timepoint: Before intervention and patient follow up for 3 and 12 months after intervention. Method of measurement: Clinical And Radiographic Assessment.	—

Measure

Time frame

Pulp revitalization. Timepoint: Before intervention and patient follow up for 3 and 12 months after intervention. Method of measurement: Clinical And Radiographic Assessment.;Changes in diameter of root dentin with the regenerated tissues. Timepoint: Before intervention and patient follow up for 3 and 12 months after intervention. Method of measurement: Clinical And Radiographic Assessment.;Changes the length of root with the regenerated tissues. Timepoint: Before intervention and patient follow up for 3 and 12 months after intervention. Method of measurement: Clinical And Radiographic Assessment.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Fariborz Moazami

Shiraz University of Medical Sciences

fmoazzami@sums.ac.ir+98 71 3626 3193

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 8, 2026