The Effect of Vitex Agnus Castus Extract on Blood Level of Prolactin & It,s Hormonal, Metabolic & Histological Effects in Comparison with Bromocriptin & Dostinex in Hyperprolactinemic Women

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200118046171N1

Enrollment

105

Registered

2020-02-03

Start date

2016-09-22

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperprolactinemia..

Interventions

Intervention 1: Intervention group: Oral bromocriptine,as protocol:1-3 tablet daily (each tablet contents 2.5 mg bromocriptine mesylate), Iran Hormone, for 4 menstrual cycles. Intervention 2: Interven

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: women with hyperprolactinemia Age 18-45 confirm letter of satisfaction

Exclusion criteria

Exclusion criteria: Pregnancy

Design outcomes

Primary

Measure	Time frame
Blood level of prolactin. Timepoint: One week before treatment,One, Two, Three & Four menstrual cycle after starting treatment. Method of measurement: sampling of blood serum.	—

Secondary

Measure	Time frame
Total Cholesterol. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;LDL Cholesterol. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;HDL Cholesterol. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;Triglyceride. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;Follicle stimulating hormone (FSH). Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;Luteinizing Hormone (LH). Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;Estradiol. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;Progesterone. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 17-22 days of menstrual cycles. Method of measurement: Vein Blood sampling.;Thickness of endometrium. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 1-3 days of menstrual cycles. Method of measurement: Abdominal Sonography.	—

Measure

Time frame

Total Cholesterol. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;LDL Cholesterol. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;HDL Cholesterol. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;Triglyceride. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;Follicle stimulating hormone (FSH). Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;Luteinizing Hormone (LH). Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;Estradiol. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 11-13 days of menstrual cycles. Method of measurement: Vein Blood sampling.;Progesterone. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 17-22 days of menstrual cycles. Method of measurement: Vein Blood sampling.;Thickness of endometrium. Timepoint: Before Intervention and for 4 cycles with Intervention, Between 1-3 days of menstrual cycles. Method of measurement: Abdominal Sonography.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNaiyereh Haerifar

Islamic Azad University

naiyereh.haerifar@gmail.com+98 41 3196 6522

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026