Probiotic nasal spray in prevention of COVID-19 and other common respiratory viruses

Investigation of probiotic nasal spray efficacy in prevention of COVID-19 and other common respiratory viruses in asthmatics children

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200117046164N2

Enrollment

Registered

2021-09-24

Start date

2021-09-23

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma. Asthma

Interventions

Intervention 1: Intervention group: probiotic nasal spray, which administer twice daily, one puff in each nostril, for one month. Lactobacillus reuteri and lactobacillus casei strains will cultured in

Eligibility

Sex/Gender

All

Age

6 Years to 18 Years

Inclusion criteria

Inclusion criteria: Asthmatic children

Exclusion criteria

Exclusion criteria: Positive history of COVID-19 Autoimmunity Malignancy Complication after nasal spray use Unwilling to continue participation in trial

Design outcomes

Primary

Measure	Time frame
Investigation of preventive effect of probiotic nasal spray in incidence of upper respiratory infection. Timepoint: Every two weeks until one month. Method of measurement: Checklist of signs and symptoms.;Axillary temperature above 38 Celsius degree. Timepoint: Every two weeks until one month. Method of measurement: Mercury thermometer placed in axillary space.;Exacerbation of Respiratory symptoms. Timepoint: Every two weeks until one month. Method of measurement: Checklist of symptoms.;Development of gasterointestinal symptoms. Timepoint: Every two weeks until one month. Method of measurement: Checklist of symptoms.;Abnormality in smell or gestatory senses. Timepoint: Every two weeks until one month. Method of measurement: Checklist of symptoms.	—

Measure

Time frame

Investigation of preventive effect of probiotic nasal spray in incidence of upper respiratory infection. Timepoint: Every two weeks until one month. Method of measurement: Checklist of signs and symptoms.;Axillary temperature above 38 Celsius degree. Timepoint: Every two weeks until one month. Method of measurement: Mercury thermometer placed in axillary space.;Exacerbation of Respiratory symptoms. Timepoint: Every two weeks until one month. Method of measurement: Checklist of symptoms.;Development of gasterointestinal symptoms. Timepoint: Every two weeks until one month. Method of measurement: Checklist of symptoms.;Abnormality in smell or gestatory senses. Timepoint: Every two weeks until one month. Method of measurement: Checklist of symptoms.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasrin Moazzen

Mashhad University of Medical Sciences

moazzenn@mums.ac.ir+98 51 3871 3801

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026