Acute kidney injury, Renal stone, Percutaneous nephrolithotomy (PCNL). Postprocedural (acute) (chronic) kidney failure
Conditions
Interventions
Intervention 1: Intervention group: Interavenous injection of 25 grams of mannitol (125 cc of 20% mannitol Serum) in 75 patients candidated for percutaneous nephrolithotomy, 15 minutes before surgery.
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients with renal stone greater than 20 mm in diameter who are candidated for percutaneous nephrolithotomy. Patients with proximal ureter stone greater than 20 mm in diameter who are candidated for percutaneous nephrolithotomy.
Exclusion criteria
Exclusion criteria: Heart failure History of lung embolism History of deep vein thrombosis History of brain edema History of intracranial hemorrhage Respiratory edema Anuria History of digoxin consumption History of Lithium consumption History of allergy to mannitol Electrolite imbalance Coagolopathies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post percutaneous nephrolithotomy glomerular filtration rate changes. Timepoint: The day before surgery, 6 hours after surgery, 1, 2, and 14 days after surgery. Method of measurement: cockroft gault equation (based on serum creatinine level). | — |
Secondary
| Measure | Time frame |
|---|---|
| Post operative hemoglobin changes. Timepoint: The day before surgery, 6 hours after surgery, 1, 2, and 14 days after surgery. Method of measurement: Complete blood count.;Post operative infection. Timepoint: The day before surgery, 6 hours after surgery, 1, 2, and 14 days after surgery. Method of measurement: Thermometer. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKaveh Mehravaran
Iran University of Medical Sciences
Outcome results
None listed