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Effect of pilocarpine mouthwash on symptoms and salivary flow rate

The evaluation of the dose-related effect of pilocarpine mouthwash on symptoms and salivary flow rate in patients with xerostomia

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200108046050N1
Enrollment
60
Registered
2021-12-01
Start date
2021-11-22
Completion date
Unknown
Last updated
2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

xerostomia. Dry mouth, unspecified

Interventions

Intervention 1: Control group: Placebo 10 ml normal saline serum, Every 8 hours, 30 drops will be mouth washed for 2 minutes. Intervention 2: Intervention group1: Pilocarpine 1% mouthwash: To prepare

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: People who have had dry mouth for 3 months or more People with age between 20 to 60 People who have informed consent to participate in the study

Exclusion criteria

Exclusion criteria: People with acute asthma attack or narrow-angle glaucoma or acute iris inflammation Women who are pregnant or breastfeeding People who have heart disease People whose dry mouth is caused by radiotherapy to the head and neck

Design outcomes

Primary

MeasureTime frame
Salivary flow rate. Timepoint: Before intervention, after 30 minutes and 2 weeks after initiation of pilocarpine mouthwash use. Method of measurement: Measurement of the volume of saliva collected in 5 minutes in a calibrated test tube.;Xerostomia symptoms. Timepoint: Before intervention, after 30 minutes and 2 weeks after initiation of pilocarpine mouthwash use. Method of measurement: Visual Analogue Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKatayoun Katebi

Tabriz University of Medical Sciences

katebik@tbzmed.ac.ir+98 41 3335 6955

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026