The effect of curcumin supplementation plus resistance training in treatment of patients with Parkinson's

Clinical trial of the effect of curcumin supplementation plus resistance training compared with the placebo on disease severity and metabolic profiles in patients with Parkinson's

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191231045968N1

Enrollment

Registered

2020-07-20

Start date

2020-06-06

Completion date

Unknown

Last updated

2020-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson disease. Parkinson's disease

Interventions

Intervention 1: 500 mg curcumin capsule ( contain 450 mg turmeric powder and 50 mg tumeric concentration equivalent with 47.5 mg curcumin) twice a day, for 8 weeks. Exercises are designed in format of

Eligibility

Sex/Gender

All

Age

50 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with Parkinson's Aged 50 to 80 years

Exclusion criteria

Exclusion criteria: Taking antioxidants supplements Taking anti-inflammatory supplements Depression Severe psychosis hypo- and hyperthyroidism Smoking Consuming curcumin supplements within 3 month prior to the study Restrictions to practicing exercise, including cardiovascular disease, stroke, respiratory problems and any surgical procedures for the treatment of PD e.g., deep brain stimulation (DBS). Motor deficits that could limit performance in exercise in the study Practicing any regular physical activity except for resistance training in the study.

Design outcomes

Primary

Measure	Time frame
Unified Parkinson's disease rating scale. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Physical Examination by Neurologist.	—

Secondary

Measure	Time frame
Insulin. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: ELISA kit.;Insulin resistance. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Calculation using HOMA formula.;Triglycerides. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;Total cholesterol. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;HDL-cholesterol. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;LDL-cholesterol. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;Fasting blood sugar. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;Malondialdehyde. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Spectrophotometry.;Glutathione. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Spectrophotometry.;Total antioxidant capacity. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Spectrophotometry.	—

Measure

Time frame

Insulin. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: ELISA kit.;Insulin resistance. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Calculation using HOMA formula.;Triglycerides. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;Total cholesterol. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;HDL-cholesterol. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;LDL-cholesterol. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;Fasting blood sugar. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Enzymatic kit.;Malondialdehyde. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Spectrophotometry.;Glutathione. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Spectrophotometry.;Total antioxidant capacity. Timepoint: At the beginning of the study and after 8 weeks of intervention. Method of measurement: Spectrophotometry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactPejman Motamedi

Kharazmi University

Pezhman.Motamedi@yahoo.com+98 26 3451 2001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026