Preeclampcia. Severe pre-eclampsia
Conditions
Interventions
Intervention 1: Intervention group: 70 mg silymarin is given immediately after delivery and 12 hours and 24 hours after delivery. Intervention 2: Intervention group: 600 mg of N-acetylcysteine is giv
Sponsors
Shahre-kord University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 30 Years
Inclusion criteria
Inclusion criteria: Maternal age is between 20 and 30 years. mothers BMI is between 20 and 24. Gestational age at termination of pregnancy is between 35 and 42 weeks. The patient's blood pressure should be greater than 140/90 mmHg before termination of pregnancy. Proteinuria, in urine random sample before pregnancy termination. Lack of history of hypertension, diabetes, kidney disease, collagen vascular disease and other cardiovascular diseases. The mother is nulipar and has no previous abortion or pregnancy. No history of smoking or alcohol in the mother. Pregnancy is single and not molar. Indication of termination of pregnancy in a patient with severe preeclampsia. The patient has complete consent to participate in the study and has signed the consent form. No incidence of eclampsia prior to inclusion.
Exclusion criteria
Exclusion criteria: Patient dissatisfaction to participate in the study Patient with eclampsia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver enzymes. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: labratoary kit.;Platlet count. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: count in mm3.;Proteinuria. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: labratoary kit.;Urea. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: mg per dl.;Creatinine. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: mg per dl.;Blood pressure. Timepoint: q 3 hours in study. Method of measurement: mmHg. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of blood pressure crisis in study. Timepoint: q 3 hours. Method of measurement: bp >160/110 mmhg. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactLeila Mahmoodnia
Shahre-kord University of Medical Sciences
Outcome results
None listed