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Investigation of immunomodulatory effects of hydroxychloroquine on pregnancy outcomes in patients with repeated implantation failure

Investigation of immunomodulatory effects of hydroxychloroquine on pregnancy outcomes in patients with repeated implantation failure (RIF)

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20191231045960N1
Enrollment
70
Registered
2020-01-19
Start date
2019-09-23
Completion date
Unknown
Last updated
2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

women infertility. Complications of attempted introduction of embryo in embryo transfer

Interventions

Intervention 1: Intervention group: Patients receive 4 mg of Estradiol valerate in the first 7 days of cycle for preparation of endometrium and 6 mg of it in the next 7 days until the endometrium is

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 42 Years

Inclusion criteria

Inclusion criteria: pregnant woman with lower than 35 years old and 3 unsuccessful IVF in embryo transfer pregnant woman with greater than 35 years old and 2 unsuccessful IVF in embryo transfer women with uterine cavity and normal thrombophilia tests and with good-quality embryos

Exclusion criteria

Exclusion criteria: Drug sensitivity patient dissatisfaction

Design outcomes

Primary

MeasureTime frame
Chemical pregnancy. Timepoint: 14 days after embryo transfer. Method of measurement: Conducting BHCG test.;Implantation rate. Timepoint: 2-4 weeks after BHCG test is positive. Method of measurement: viewing the number of gestational sacs using ultrasound scan.;Clinical pregnancy. Timepoint: 3-5 weeks after BHCG test is positive. Method of measurement: viewing the live fetus using ultrasound scan.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElahe Akhgari

Mashhad University of Medical Sciences

akhgarie971@mums.ac.ir+98 51 3802 2608

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026