The Effect of Combined Supplementation of Berberine and Fenugreek Seed Powder on Inflammatory Factors and Lipid and Glucose Profile in Patients with Type 2 Diabetes

Comparison of the combined efficacy of berberine and fenugreek in controlling blood glucose and lipid profile and inflammatory factors in type 2 diabetic patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191229045937N1

Enrollment

Registered

2020-02-02

Start date

2019-12-29

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes. Diabetes mellitus due to underlying condition

Interventions

Intervention 1: Intervention group: We selected 25 patients with type 2 diabetes between the ages of 25-65 years based on inclusion and exclusion criteria. Each person consumes 3 capsules of 500 mg da

Eligibility

Sex/Gender

All

Age

25 Years to 65 Years

Inclusion criteria

Inclusion criteria: Having over 25BMI, at least 1 year of diabetes, 25-65 year olds with type 2 diabetes, taking blood sugar lowering diabetes medications, no pregnancy and lactation, no chronic diseases (liver, kidney, heart, thyroid, Rheumatic, Pulmonary, Metabolic, Digestive, Malignancies, Allergies), No insulin requirement, No use of dietary supplements, vitamins and minerals at least 3 months before study, No hormone therapy, No smoking, No use of other medicinal products Routine face at least 3 months before study, written informed consent from patients at least 1 year of diabetes 25-65 year olds with type 2 diabetes taking blood sugar lowering diabetes medications no pregnancy and lactation no chronic diseases (liver, kidney, heart, thyroid, Rheumatic, Pulmonary, Metabolic, Digestive, Malignancies, Allergies) No insulin requirement No use of dietary supplements, vitamins and minerals at least 3 months before study No hormone therapy No smoking No use of other medicinal products Routine face at least 3 months before study written informed consent from patients

Exclusion criteria

Exclusion criteria: Not willing to continue cooperation Specific diseases (liver, kidney, heart, thyroid, rheumatic, pulmonary, metabolic, gastrointestinal, malignant, allergic) during study pregnancy initiation and lactation Start insulin treatment Start taking supplements, vitamins and minerals Changes in the dosage of oral hypoglycemic agents Changes in the amount of physical activity during the study Start taking other medicinal products routinely Pregnant and lactating women Past 6 months drug or alcohol use history Taking steroidal anti-inflammatory drugs and fiber supplements Weight loss diet at least 6 months before the intervention Use of dietary supplements and other herbal remedies at least 3 months before intervention

Design outcomes

Primary

Measure	Time frame
Inflammatory factors and lipid and sugar profiles. Timepoint: Evaluation of inflammatory factors and lipid profile and glucose profile at baseline and 12 weeks after starting supplementation with berberine and fenugreek. Method of measurement: Blood serum separation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShima Nematollahi

Ahvaz University of Medical Sciences

Shimanematollahi7@gmail.com+98 61 3321 4578

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026