The effect of two different doses of the drug on hemodynamic responses in patients undergoing laparoscopic cholecystectomy

Comparison study of two doses of magnesium sulfate on hemodynamic response to endotracheal intubation in laparoscopic cholecystectomy

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191229045935N1

Enrollment

Registered

2020-03-04

Start date

2019-02-27

Completion date

Unknown

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing CABG.

Interventions

Intervention 1: Intervention group: Magnesium sulfate 30mg / kg infusion within 5 minutes which continues before induction. The studied drugs were manufactured by Judge Tabriz Company from Alborz Broa

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: ASA II-III Patients Candidate for Laparoscopic Elective Cholecystectomy

Exclusion criteria

Exclusion criteria: Emergency Surgery Probability of intubation problem Sensitivity to magnesium sulfate Cardiac arrhythmia Serum creatinine above 2 mg / dl pregnant women Patients with severe heart valve disorders Patients with aortic stenosis

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: At the time of tracheal, and 2, 4, 6, and 10 minutes after tracheal intubation. Method of measurement: Digital barometer.;Systolic blood pressure, diastolic blood pressure, and mean blood pressure. Timepoint: systolic blood pressure, diastolic blood pressure, and mean blood pressure before infusion to induction were recorded at different time points, including anesthesia induction, at the time of tracheal, and 2, 4, 6, and 10 minutes after tracheal intubation. Method of measurement: Mercury barometer.	—

Measure

Time frame

Heart rate. Timepoint: At the time of tracheal, and 2, 4, 6, and 10 minutes after tracheal intubation. Method of measurement: Digital barometer.;Systolic blood pressure, diastolic blood pressure, and mean blood pressure. Timepoint: systolic blood pressure, diastolic blood pressure, and mean blood pressure before infusion to induction were recorded at different time points, including anesthesia induction, at the time of tracheal, and 2, 4, 6, and 10 minutes after tracheal intubation. Method of measurement: Mercury barometer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactJafar Kazemeini

Kashan University of Medical Sciences

kazemeini-j@mail.kaums.ac.ir+98 31 5550 0111

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026