Investigation of Methylene Blue for treatment of COVID-19 outpatients referred to pulmonary clinic.

Application of Methylene Blue Along with Complementary Materials for Treatment of COVID-19 Outpatients with Less Than 8 Days from First Day of Clinical Symptoms

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191228045924N2

Enrollment

240

Registered

2021-11-22

Start date

2021-11-25

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. U07.1

Interventions

Intervention 1: Intervention group: In addition to the standard treatment, Covid-19 outpatients are received orally methylene blue along with complementary materials two times per day in interval time

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Outpatient COVID-19 patients who confirmed by PCR or HRCT referred to pulmonary clinic SPO2 is between 70-96 after taking off the mask

Exclusion criteria

Exclusion criteria: Pregnancy Severe impairment of liver and heart Renal insufficiency including severe renal impairment G6PD enzyme deficiency

Design outcomes

Primary

Measure	Time frame
Oxygen pressure saturation. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Pulse oximeter.;Respiratory Rate. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Headache. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Cough. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Shivery. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Chest pain. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Vomiting. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Diarrhea. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Fever. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.	—

Measure

Time frame

Oxygen pressure saturation. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Pulse oximeter.;Respiratory Rate. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Headache. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Cough. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Shivery. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Chest pain. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Vomiting. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Diarrhea. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.;Fever. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam.

—

Secondary

Measure	Time frame
Hospital stay time. Timepoint: After 15 days. Method of measurement: Number of days.;Mortality rate. Timepoint: After 30 days. Method of measurement: Review of medical records.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contact?Dr. Daryoush Hamidi Alamdari

Mashhad University of Medical Sciences

hamidiad@mums.ac.ir+98 51 3882 8574

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026