Effect of Allopurinol in treatment of patients with Non ST-segment elevation myocardial infarction

Effect of high dose of Allopurinol loading on level of inflammatory markers and in hospital composite events in Non ST-segment elevation myocardial infarction patients who refer to chamran hospital in Esfahan city.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191223045866N1

Enrollment

Registered

2020-02-28

Start date

2019-09-23

Completion date

Unknown

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute myocardial infarction without ST segment elevation. Subsequent ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction

Interventions

Intervention 1: Intervention group: 600 mg loading dose of allopurinol before angiography. Intervention 2: Control group: Treatment with placebo similar in shape, color and size before angiography.

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Ischemic type chest pain Non ST-segment elevation Positive troponin biomarker Age of patient between 18-85

Exclusion criteria

Exclusion criteria: History of Allopurinol consumption Cardiogenic shock Pulmonary edema with functional class III orIV Ventricular tachycardia or ventricular fibrillation

Design outcomes

Primary

Measure	Time frame
Inflammatory markers including highly sensitive C-reactive protein and highly sensitive cardiac troponin. Timepoint: Before the angiography and within 24 hours after acute myocardial infarction. Method of measurement: Blood sampling and laboratory assessment.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Asadi

Esfahan University of Medical Sciences

asadiali.689@gmail.com+98 31 3651 2852

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026