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Effect of Crocin in treatment of depression

Comparison of Crocin and Sertraline in treatment of major depressive disorder

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20191222045851N1
Enrollment
40
Registered
2020-05-31
Start date
2019-07-18
Completion date
Unknown
Last updated
2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder. Major depressive disorder, single episode, mild

Interventions

Intervention 1: control group: Patients received 2 oral capsules/day containing 15 mg of Crocin for 6 consecutive weeks. Crosin is a carotenoid that is extracted and purified from saffron that made a

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Having diagnostic criteria for depression Patient consent to participate in the study

Exclusion criteria

Exclusion criteria: Those who are psychotic. Those who had thoughts or attempted suicide in the past or present. Those who have substance abuse. Those with recurrent depression Those whose recent episodes are severe

Design outcomes

Primary

MeasureTime frame
Depression Score. Timepoint: At the beginning (before intervention), on third week of study and the sixth week after intervention. Method of measurement: Hamilton Depression Rating Scale.;Anxiety Score. Timepoint: At the beginning, on third week of study and the sixth week after intervention. Method of measurement: Hamilton Anxiety Rating Scale.

Secondary

MeasureTime frame
Therapeutic Effect Score. Timepoint: The timing of measuring the therapeutic effect as secondary outcome in third week and 6th week after using Crocin and Serteralin pills. Method of measurement: Clinical Global Improvement Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactTalaei Ali

Mashhad University of Medical Sciences

pbsrc@mums.ac.ir+98 51 3711 2540

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026