Study of the effect of desmopressin injection on intraoperative hemorrhage of lumbar disc herniation Outcome variable

Comparisson of the effect of preoperative intravenous desmopressin on postoperative and during operation blood loss in patients undergoing major spine surgery

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191221045840N1

Enrollment

Registered

2020-01-20

Start date

2019-12-22

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lumbosacral disc herniation. Other intervertebral disc degeneration, lumbosacral region

Interventions

Intervention 1: The intervention group: DDAVP drug delivered group was desmopressin. Vasopressin Analogue increased Willebrand factor 8. The injected drug was used in this study. The dose of each Ampo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: thoracolumbosacral fracture degenerative lumbosacral disease hypertension & coagulation disorders all types of traumatic patient Consent to enter the research project

Exclusion criteria

Exclusion criteria: acute heart disease polydipsia chronic heart failure hypothermia chronic kidney disease & end stage renal disease

Design outcomes

Primary

Measure	Time frame
In this study, the main variable is intra and postoperative hemorrhage. Timepoint: From operation until 24 hours after the operation. Method of measurement: In this study, the intraoperative hemorrhage in Drain and the amount of Gauze consumed was measured and counted in the operating room (each Gauze is equal to 30-50 cc). also, the blood in the drain was measured until 24 hours.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactali alizadeh

Qazvin University of Medical Sciences

mahsa.92vafaee@yahoo.com+98 21 3327 2257

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026