Comparison of the effect of dexmedetomidine and magnesium sulfate in patients undergoing laparoscopic cholecystectomy

Comparison of the effect of dexmedetomidine and magnesium sulfate in controlling hemodynamic changes in patients undergoing laparoscopic cholecystectomy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191220045829N1

Enrollment

Registered

2021-09-27

Start date

2017-09-23

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparoscopic cholecystectomy. Calculus of gallbladder without cholecystitis

Interventions

Intervention 1: Intervention group: Dexmedetomidine 1µg/kg was injected intravenously in 20 ml normal saline for ten minutes before induction of anesthesia, and dexmedetomidine 0.5µg/kg per hour after

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients Candidate for Laparoscopic Cholecystectomy Surgery in Kashan Shahid Beheshti Hospital Patients 18-65 years Level one and two class A.S.A (American society of anesthesiologists) Blood pressure less than or equal to 140/190

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: It was recorded by a monitor device attached to the patient.;Diastolic blood pressure. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: It was recorded by a monitor device attached to the patient.;Mean arterial blood pressure. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: It was recorded by a monitor device attached to the patient.;Heart Rate. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: It was recorded by a monitor device attached to the patient.;O2 saturation. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: Pulse oximtery.;Intra-abdominal pressure. Timepoint: every 10 minutes up to 40 minutes. Method of measurement: Manometer.;End-Tidal CO2. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: Capnograph device.;Bispectral index. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: It was recorded by a monitor device attached to the patient.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: It was recorded by a monitor device attached to the patient.;Diastolic blood pressure. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: It was recorded by a monitor device attached to the patient.;Mean arterial blood pressure. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: It was recorded by a monitor device attached to the patient.;Heart Rate. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: It was recorded by a monitor device attached to the patient.;O2 saturation. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: Pulse oximtery.;Intra-abdominal pressure. Timepoint: every 10 minutes up to 40 minutes. Method of measurement: Manometer.;End-Tidal CO2. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: Capnograph device.;Bispectral index. Timepoint: Before and after pre-drug injection, after induction, after intubation, after blowing gas, every 10 minutes up to 40 minutes and after extubation. Method of measurement: It was recorded by a monitor device attached to the patient.

—

Secondary

Measure	Time frame
Recovery time. Timepoint: From the the rejection of patient's endotracheal intubation to the number 9 of the Aldrete criteria. Method of measurement: Aldrete criteria.;Rate of usage of Propofol. Timepoint: One time at the end of surgery. Method of measurement: The mean dose per kilogram of body weight per minute.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEmad Khan ahmad

Kashan University of Medical Sciences

reza.2240power@gmail.com+98 31 5554 0026

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026