Evaluation of the Effect of Donepezil on the Methadone Consumption

Evaluation of the Effect of Donepezil on the Methadone Consumption in Methadone Maintenance

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191217045766N1

Enrollment

100

Registered

2021-11-24

Start date

2021-12-16

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

amount of Methadon use.

Interventions

Dopezil Sobhan Pharmaceutical Company Start with 5 mg oral tablets once a day for 4 weeks and then 10 mg tablets once a day until the end of week 14.

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: All opioid dependent patients on Methadone agonist therapy in the age range of 18 to 55 years At least fifth grade elementary education

Exclusion criteria

Exclusion criteria: Intellectual Disability Use if Anti Depressant, Carbamazepin, Dexamethasone, Phenobarbital, Phenytoin, Rifampin, Clonidine, Sox, Betanecol Use of Donepezil during 3 months ago CAD Pregnancy and Lactation major psychiatric disorder Use of Psychotherapy Sever sensitivity to Donepezil

Design outcomes

Primary

Measure	Time frame
Amount of Methadon use. Timepoint: at the beginning of the study,weeks of 4, 10 and 14. Method of measurement: patients report.;Craving for Methadon. Timepoint: at the beginning of the study,weeks of 4, 10 and 14. Method of measurement: HALIKAS Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactModabber Arasteh

Kurdistan University of Medical Sciences

arastehmd@yahoo.com+98 87 3366 0026

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026