Comparison of Curcuma and Russian olive in the Treatment of Knee Osteoarthritis

The effectiveness of Turmeric extract (Curcuma) versus Russian olive extract on the pain, function and quality of life in the patients with knee osteoarthritis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191216045760N1

Enrollment

Registered

2020-02-15

Start date

2020-02-29

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of knee. Osteoarthritis of knee

Interventions

Intervention 1: The itervention group will be orally treated with 250 mg Elartrit capsules (containing Russian olive extract) of Reyhaneh Isfahan Pharmaceutical Company (every 12 hours for 15 days, af

Eligibility

Sex/Gender

All

Age

45 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients older than 45 years Patients diagnosed with knee osteoarthritis according to the American College of Rheumatology criteria with symptoms for at least 3 months Knee X-ray as grade 2 or 3 of Kellgren-Lawrence (K-L) classification Patients' willingness to participate in the study after providing complete information about the project's goals

Exclusion criteria

Exclusion criteria: Clinical findings in other joints of the body such as hip, wrist or spine. Evidence of neuropathy such as radiculopathy or peripheral neuropathy Systemic inflammatory disease such as RA, AS Fibromyalgia or endocrine and metabolic diseases Corticosteroid use in the past 48 hours or intra-articular injection of Corticosteroid in the past 4 months Taking NSAIDs in the past week Psychiatric disease Severe blood dyscrasia, coagulopathy, current warfarin use Liver failure or liver tests more than 1.5 times of normal values Biliary Disease PUD or reflux history (GERD) Renal Failure - Uncontrolled hypertension Lack of medication compliance in the patient

Design outcomes

Primary

Measure	Time frame
Knee pain intensity. Timepoint: Before treatment, 2 and 4 weeks after treatment. Method of measurement: VAS (Visual Analogue Scale).;Symptoms of disease and quality of life. Timepoint: Before treatment, 2 and 4 weeks after treatment. Method of measurement: Knee injury and Osteoarthritis Outcome Score (KOOS).;Function. Timepoint: Before treatment, 2 and 4 weeks after treatment. Method of measurement: Roles and Maudsley score.	—

Measure

Time frame

Knee pain intensity. Timepoint: Before treatment, 2 and 4 weeks after treatment. Method of measurement: VAS (Visual Analogue Scale).;Symptoms of disease and quality of life. Timepoint: Before treatment, 2 and 4 weeks after treatment. Method of measurement: Knee injury and Osteoarthritis Outcome Score (KOOS).;Function. Timepoint: Before treatment, 2 and 4 weeks after treatment. Method of measurement: Roles and Maudsley score.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSadegh Baradaran Mahdavi

Esfahan University of Medical Sciences

sadegh.b.mahdavi@gmail.com+98 31 3236 0339

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026