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Th effect of topical formulation of black pepper oil in patients with knee osteoarthritis

Randomized double-blind controlled clinical trial to evaluate the effect of a topical formulation containing black pepper oil on pain control and performance improvement in patients with knee osteoarthritis

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20191212045709N4
Enrollment
30
Registered
2025-05-01
Start date
2025-05-20
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: Patients who underwent intra-articular injection of Hyaluronic Acid were included in the study. One week after intra-articular injection of hyaluronic acid, topical

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with grade III-II knee abrasion based on radiological imaging. Patients with the chief complain of knee pain. Patients with knee osteoarthritis confirmed in radiologic examination. Patients aged between 40-80 years old. Patients with class I, II based on the ASA criteria.

Exclusion criteria

Exclusion criteria: Diabetes Connective Tissue Disease Vascular Peripheral Disease Alzheimer Disease Lower Limb Motor Disorders Neurologic or Psychiatric Disorders Pregnant Woman Lactating Woman

Design outcomes

Primary

MeasureTime frame
Knee pain. Timepoint: Before the intervention, 4, and 12 weeks after the initiation of the intervention. Method of measurement: Changes in scores of VAS and WOMAC questionnaires.;Functionality. Timepoint: At baseline and after 4 and 12 weeks after the initiation of the intervention. Method of measurement: Changes in WOMAC questionnaire scores.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Mehdi Zarshenas

Shiraz University of Medical Sciences

zarm@sums.ac.ir+98 917 117 3491

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026