Assessment of the effect of aspirin on periapical inflammation

Assessment of the effect of aspirin on levels of lipoxin A4? interleukin-1ß and prostaglandin E2 in periapical exudates: a double blinded randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191211045702N1

Enrollment

Registered

2019-12-23

Start date

2020-01-21

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Apical periodontitis. Chronic apical periodontitis

Interventions

Intervention 1: Intervention group: 7 pills of aspirin 80 mg for 7 days. Intervention 2: Control group: 7 tablets containing sodium saccharin for 7 days.

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Patients with good general health Patients aged 18-45 years All single root, distal root of mandibular molars and palatal root of maxillary molars with periapical lesion of >5 mm in diameter Tooth with no history of trauma and previous root canal treatment

Exclusion criteria

Exclusion criteria: Unable to isolate tooth Presence of periodontal disease Presence of systemic disease History or presence of other infections Specific physiological conditions Oral ulcer Smokers and alcoholics Gastrointestinal problems Treatment with any drug over the past week Sensitivity to salicylates or other non-steroidal anti-inflammatory drugs

Design outcomes

Primary

Measure	Time frame
Concentration of inflammatory mediator. Timepoint: At baseline and 7 days later. Method of measurement: Enzyme-linked immunosorbent kit.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRazieh Salehi

Hamedan University of Medical Sciences

r.salehi70510@gmail.com+98 81 3838 1086

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 10, 2026