Depression,Hypogonadism.
Conditions
Interventions
Intervention 1: first intervention group : Patients receiving 10 g of testosterone 1% gel once a day in addition to previous medications. Intervention 2: Seconde intervention group:Patients receiving
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: Depression(Hamilton Score =>12) Not responded to a 6-week trial of antidepressant drugs testosterone level less than 350ng/dl
Exclusion criteria
Exclusion criteria: Acute phase of psychotic symptoms including hallucinations and delusions Bipolar disorder drug addicted Testosterone level > 350ng/dl Suicide or attempted to suicide in the last 3 months Dementia PSA > 4ng/dl Prostate cancer history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score in Hamilton questionnaire. Timepoint: before the intervention and 1 month, 2 months and 3 months after the start of testosterone gel. Method of measurement: Hamilton questionnaire.;Testosterone level. Timepoint: before the intervention and 1 month, 2 months and 3 months after the start of testosterone gel. Method of measurement: Blood test to measure testosterone level. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sexual function score. Timepoint: Before the intervention and 3 months after taking testosterone gel. Method of measurement: IIEF questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNahid Tavakoli
Tehran University of Medical Sciences
Outcome results
None listed