Effectiveness of duloxetine in posterior spinal fixation.
Conditions
Interventions
Intervention 1: Intervention group: After posterior spinal fixation surgery case group receive 30 mg of duloxetine for 6 weeks. Intervention 2: Control group: : After posterior spinal fixation surgery
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients older than 18 years old and younger than 80 with chronic low back pain (more than 3 months duration) who are candidate for posterior spinal fixation surgery. All patients have to discontinue any medication that could interfere with their pain such as nonopioid or opioid drugs , antidepressants and anticonvulsants at least for 6 months before surgery. Non pharmacological pain-relieving procedures such as acupuncture or physical therapies are not allowed during the study.
Exclusion criteria
Exclusion criteria: prior use of opioids , antidepressants , drug abuse depression pregnancy and breast feeding severe coexisting diseases such as heart failure , severe hypertension , convulsion and kidney dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness of duloxetine on quality of life in chronic low back pain in patients who had posterior spinal fixation measured with SF36 questionnaire / Effectiveness of duloxetine on severity of pain in chronic low back pain in patients who had posterior spinal fixation measured with VAS questionnaire. Timepoint: all patients will fill the questionnaires at first step of study and one more 6 weeks later. Method of measurement: SF36 questionnaire / VAS questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactArezoo Samadi
Iran University of Medical Sciences
Outcome results
None listed