Correction of Complications of Poly Cystic Ovary Syndrome by Alpha lipoic Acid in Undergoing ICSI Treatment Women

Effect of Combination of Alpha Lipoic Acid and Metformin on Biochemical Factors of Follicular Fluid, Oocytes Maturation, Embryos Quality and Number and Pragnancy Rate in Patients with PCOs Undergoing ICSI Treatment

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191210045681N1

Enrollment

Registered

2020-01-19

Start date

2020-01-30

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Poly Cystic Ovarian Syndrome. E28.2: Polycystic Ovarian Syndrome

Interventions

Intervention 1: Control Group: Metformin, 500 mg Three Times Daily for 8 Weeks. Intervention 2: Intervention Group: Alpha Lipoic Acid (600 mg daily for 8 weeks) and Met formin (500 mg daily for 8 week

Eligibility

Sex/Gender

Female

Age

25 Years to 35 Years

Inclusion criteria

Inclusion criteria: Periodic Disorders (Oligomenorrhea or Amenorrhea Patients). Hirsutism, Infertility LH / FSH Ratio Increased Ultrasound View of Ovary Size and Multiple Follicles 2-10 mm in Size Normal Sperm Analysis Normal Thyroid Function and Prolactin Levels Natural Hystero Salpingography No Endometriosis

Exclusion criteria

Exclusion criteria: Non-Ovulatory Infertility Factors Male Factor Infertility Pelvic Organ Damage Congenital Adrenal Hyperplasia Thyroid Dysfunction Cushing's Syndrome Severe or Renal Liver Diseases Active Gastric Ulcer

Design outcomes

Primary

Measure	Time frame
Measurement of Biochemical Markers. Timepoint: Before and 8 Weeks after Drug Administration. Method of measurement: Elisa Kit.;Stress Oxidative Level. Timepoint: 8 Weeks. Method of measurement: Laboratory Kits.;Oocyte and Embryo Quality. Timepoint: 8 Weeks. Method of measurement: Shape and Morphology.	—

Secondary

Measure	Time frame
Pregnancy Rate. Timepoint: 8 Weeks. Method of measurement: Laboratory Kits.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElham Asa

Iranian academic center for education culture and research

Asa.Elham@gmail.com+98 25 3270 3987

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026