Effect of Bupropion in prostatitis treatment

Comparison of Bupropion SR with Duloxetine on pelvic pain reduction in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191205045621N1

Enrollment

Registered

2020-03-04

Start date

2020-03-05

Completion date

Unknown

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Pelvic Pain Syndrome/ Chronic Prostatitis. Chronic prostatitis

Interventions

Intervention 1: Intervention group: Bupropion SR tablet (Abidi)150 milligrams daily for 3 months. Intervention 2: Control group: Duloxetine 60 milligrams capsule daily for 3 months.

Eligibility

Sex/Gender

Male

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: CP/CPPS patients with pain symptom in the pelvic area for at least 3 months Age of 18 to 50 years old No prior history of other genitourinary tract disorders such as urinary stones, urethral stricture, neurogenic bladder, urinary infection No prior history of pelvic organ or urinary system surgery No history of pelvic organ or urinary tract cancers No history of renal failure or cirrhosis No history of psychosis or mania

Exclusion criteria

Exclusion criteria: Incomplete questionnaire Intolerable medication side-effects Taking antidepressant medications, alpha-blockers, 5 alpha-reductase inhibitors, analgesics Opiates use Taking medications that can interact with Bupropion or Duloxetine

Design outcomes

Primary

Measure	Time frame
Pain severity. Timepoint: Before intervention and 4, 12, 16 weeks after intervention. Method of measurement: Short form McGill pain questionnaire.;Quality of life. Timepoint: Before intervention and 4, 12, 16 weeks after intervention. Method of measurement: 12-Item Short-Form Health Survey.;Sexual function. Timepoint: Before intervention and 4, 12, 16 weeks after intervention. Method of measurement: Arizona Sexual Experience Scale (ASEX).;Depression. Timepoint: Before intervention and 4, 12, 16 weeks after intervention. Method of measurement: Hospital Anxiety and Depression Scale.;Anxiety. Timepoint: Before intervention and 4, 12, 16 weeks after intervention. Method of measurement: Hospital Anxiety and Depression Scale.	—

Measure

Time frame

Pain severity. Timepoint: Before intervention and 4, 12, 16 weeks after intervention. Method of measurement: Short form McGill pain questionnaire.;Quality of life. Timepoint: Before intervention and 4, 12, 16 weeks after intervention. Method of measurement: 12-Item Short-Form Health Survey.;Sexual function. Timepoint: Before intervention and 4, 12, 16 weeks after intervention. Method of measurement: Arizona Sexual Experience Scale (ASEX).;Depression. Timepoint: Before intervention and 4, 12, 16 weeks after intervention. Method of measurement: Hospital Anxiety and Depression Scale.;Anxiety. Timepoint: Before intervention and 4, 12, 16 weeks after intervention. Method of measurement: Hospital Anxiety and Depression Scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShokufe Jafari

Esfahan University of Medical Sciences

Jafarish@resident.mui.ac.ir+98 31 3222 2475

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026