Evaluation of Double dose Ketamine Prescription in Prevention of Fentanyl Induced Cough

Evaluation of Double Dose Ketamine prescription in Prevention of Fentanyl Induced Cough During Anesthetic Induction in Children between 6months to 2years

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191128045536N1

Enrollment

132

Registered

2020-03-16

Start date

2020-04-03

Completion date

Unknown

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of Fentanyl induced cough.

Interventions

Intervention 1: Intervention group: 0/1 mg/kg ketamin intra vain. Intervention 2: Intervention group: 0/2 mg/ kg ketamin intra vain. Intervention 3: Control group: normal salin 0/9% Equal volume.

Eligibility

Sex/Gender

All

Age

6 Months to 2 Years

Inclusion criteria

Inclusion criteria: Children between 6months to 2years Candidate Surgery under General Anesthesia

Exclusion criteria

Exclusion criteria: Symptoms of Cold Last Two Week History of Irritable Airway Disease History of Asthma Convulsion Increase Intracranial Pressure Probability of Intubation Problem

Design outcomes

Primary

Measure	Time frame
Pulse rate. Timepoint: 1 minute before administration of Ketamine, 1 minute after administration of Ketamine, 1 minute before administration of fentanyl, 1 minute after administration of fentanyl. Method of measurement: Monitoring by pulse Oximeter.;Mean arterial pressure. Timepoint: 1 minute before administration of Ketamine, 1 minute after administration of Ketamine, 1 minute before administration of fentanyl, 1 minute after administration of fentanyl. Method of measurement: Monitoring by Manometer.;Incidence of cough. Timepoint: 1 minute after administration of fentanyl, 3 minute after administration of fentanyl. Method of measurement: Observation.;Severity of cough. Timepoint: 1 minute after administration of fentanyl, 3 minute after administration of fentanyl. Method of measurement: Observation.;Oxygen saturation percentage. Timepoint: 1 minute before administration of Ketamine, 1 minute after administration of Ketamine, 1 minute before administration of fentanyl, 1 minute after administration of fentanyl. Method of measurement: Monitoring by pulse Oximeter.	—

Measure

Time frame

Pulse rate. Timepoint: 1 minute before administration of Ketamine, 1 minute after administration of Ketamine, 1 minute before administration of fentanyl, 1 minute after administration of fentanyl. Method of measurement: Monitoring by pulse Oximeter.;Mean arterial pressure. Timepoint: 1 minute before administration of Ketamine, 1 minute after administration of Ketamine, 1 minute before administration of fentanyl, 1 minute after administration of fentanyl. Method of measurement: Monitoring by Manometer.;Incidence of cough. Timepoint: 1 minute after administration of fentanyl, 3 minute after administration of fentanyl. Method of measurement: Observation.;Severity of cough. Timepoint: 1 minute after administration of fentanyl, 3 minute after administration of fentanyl. Method of measurement: Observation.;Oxygen saturation percentage. Timepoint: 1 minute before administration of Ketamine, 1 minute after administration of Ketamine, 1 minute before administration of fentanyl, 1 minute after administration of fentanyl. Method of measurement: Monitoring by pulse Oximeter.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmir Shafa

Esfahan University of Medical Sciences

amir_shafa@med.mui.ac.ir+98 31 3386 9141

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026