Effect of vitamin A injection on healing of anastomosis

Effect of vitamin A injection on healing of anastomosis in patients with gastrointestinal cancer

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191127045520N1

Enrollment

140

Registered

2020-02-04

Start date

2020-01-21

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anastomosis leakage in gastrointestinal cancer. Intestinal bypass and anastomosis status

Interventions

Intervention 1: Intervention group: Intramuscular injection of vitamin A at a dose of 50000 international units (One milliliter) , daily, for 3 days after surgery. Intervention 2: Control group: Intra

Eligibility

Sex/Gender

All

Age

No minimum to 75 Years

Inclusion criteria

Inclusion criteria: People with one of the types of gastrointestinal cancers, including gastric, colon and rectum that undergo gastrointestinal surgery and anastomosis.

Exclusion criteria

Exclusion criteria: Malnutrition History of Alcohol Use History of corticosteroids Use Multiple blood transfusions In operation Emergency surgery Surgery following recurrence the disease

Design outcomes

Primary

Measure	Time frame
Anastomosis Leakage. Timepoint: 5 days after surgery. Method of measurement: Clinical signs including fever, biliary secretion, leukocytosis , Peritonitis and the need for reoperation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHaniyeh Dehghan Chenari

Yazd University of Medical Sciences

haniyehdehghanch74@gmail.com+98 35 3312 2001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026