The effect of Aerobic Exercise with Sertraline On Patients after Coronary Artery Bypass Graft Surgery

The Effect of Eight Weeks Aerobic Exercise and Sertraline Intake on Neurotrophic Factors, Inflammatory, Depressive, and Quality of Life of Patients after Coronary Artery Bypass Graft Surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191125045496N1

Enrollment

Registered

2020-04-17

Start date

2019-08-11

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients after coronary artery bypass surgery(CABG). Atherosclerosis of coronary artery bypass graft(s) and coronary artery of transplanted heart with angina pectoris

Interventions

Intervention 1: Intervention 1: Aerobic training group:Aerobic exercise for eight weeks (three sessions per week) consisted of 50-70% of maximal heart rate training for 20 to 40 minutes on the treadmi

Eligibility

Sex/Gender

Male

Age

40 Years to 60 Years

Inclusion criteria

Inclusion criteria: The patients who underwent CABG surgery for the first time. They will range from 40 to 60 years in age. At least 2 to 6 months have elapsed since CABG surgery. Anxiety and depression scores based on the HADS score of 8 or higher.

Exclusion criteria

Exclusion criteria: Having unstable angina pectoris and complicated ventricular arrhythmias Not having a heart failure Having regular exercise history Patient history of taking sertraline, or other antidepressant and anxiety medications

Design outcomes

Primary

Measure	Time frame
Depression and anxiety. Timepoint: At baseline (before intervention) and 8 weeks after intervention. Method of measurement: Hospital Anxiety and Depression Scale (HADS).;Quality of Life. Timepoint: At baseline (before intervention) and 8 weeks after intervention. Method of measurement: Short Form Quality of Life Questionnaire (SF-36).;Brain-derived neurotrophic factor. Timepoint: At baseline (before intervention) and 8 weeks after intervention. Method of measurement: By Eliza's research kit.;Interleukin-6. Timepoint: At baseline (before intervention) and 8 weeks after intervention. Method of measurement: By Eliza's research kit.;C-Reactive Protein. Timepoint: At baseline (before intervention) and 8 weeks after intervention. Method of measurement: By Eliza's research kit.	—

Measure

Time frame

Depression and anxiety. Timepoint: At baseline (before intervention) and 8 weeks after intervention. Method of measurement: Hospital Anxiety and Depression Scale (HADS).;Quality of Life. Timepoint: At baseline (before intervention) and 8 weeks after intervention. Method of measurement: Short Form Quality of Life Questionnaire (SF-36).;Brain-derived neurotrophic factor. Timepoint: At baseline (before intervention) and 8 weeks after intervention. Method of measurement: By Eliza's research kit.;Interleukin-6. Timepoint: At baseline (before intervention) and 8 weeks after intervention. Method of measurement: By Eliza's research kit.;C-Reactive Protein. Timepoint: At baseline (before intervention) and 8 weeks after intervention. Method of measurement: By Eliza's research kit.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Hamzeh Hosseini

Mazandaran University of Medical Sciences

hosseinish20@gmail.com+98 11 3310 9231

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026