Effect of Ozone therapy in treatment of COVID-19

Comparison of the effectiveness of Ozone therapy with conventional therapy in improving patient outcomes in Covid-19 patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191125045492N2

Enrollment

Registered

2020-04-18

Start date

2020-04-23

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19, virus not identified

Interventions

Intervention 1: Intervention group: In addition to the conventional treatments for Covid-19, patients will undergo a cycle of Ozone Major Autohemotherapy. In this method, a specific volume of patient

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who have been diagnosed with COVID-19

Exclusion criteria

Exclusion criteria: Patients with hypersensitivity to ozone Patients with abnormal thyroid function tests Patients with abnormal coagulation tests Patients with G6PD deficiency Pregnant or lactating women

Design outcomes

Primary

Measure	Time frame
Quantitative CRP. Timepoint: Before and after the intervention. Method of measurement: Lab kit.;Oxygen Saturation. Timepoint: Before and after the intervention. Method of measurement: Pulse Oximetry.;Body's temperature. Timepoint: Before and after the intervention. Method of measurement: Thermometer.;Dyspnea. Timepoint: Before and after the intervention. Method of measurement: Subjective assessment of the patient and physical examination.;Cough. Timepoint: Before and after the intervention. Method of measurement: subjective assessment of the patient.;Diarrhea. Timepoint: before and after the intervention. Method of measurement: subjective assessment of the patient.;Headache. Timepoint: Before and after the intervention. Method of measurement: Subjective assessment of the patient.;Chills. Timepoint: Before and after the intervention. Method of measurement: Subjective assessment of the patient.	—

Measure

Time frame

Quantitative CRP. Timepoint: Before and after the intervention. Method of measurement: Lab kit.;Oxygen Saturation. Timepoint: Before and after the intervention. Method of measurement: Pulse Oximetry.;Body's temperature. Timepoint: Before and after the intervention. Method of measurement: Thermometer.;Dyspnea. Timepoint: Before and after the intervention. Method of measurement: Subjective assessment of the patient and physical examination.;Cough. Timepoint: Before and after the intervention. Method of measurement: subjective assessment of the patient.;Diarrhea. Timepoint: before and after the intervention. Method of measurement: subjective assessment of the patient.;Headache. Timepoint: Before and after the intervention. Method of measurement: Subjective assessment of the patient.;Chills. Timepoint: Before and after the intervention. Method of measurement: Subjective assessment of the patient.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Sarrafzadeh

Bagheiat-allah University of Medical Sciences

ali_sarrafzadeh@yahoo.com+98 13 3324 7683

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026