Participants are patients with psoriasis. Psoriasis is a skin condition that appears in the form of thick white-silver skins and itchy plaques on the surface of the skin..
Conditions
Interventions
Intervention 1: Intervention group: Will intake 2 capsules orally in a day that containing probiotic supplements at least 1.6× 109 cfu/g of probiotics including (Lactobacillus acidophilus, Bifidobac
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Patients with the diagnosis of the medium to severe psoriasis are based on the classification criteria for Psoriasis vulgaris. Patients aged between 18 and 50 (until the date of screening) The inclusion of participants in the study is informed by the understanding of all the procedures of the study, voluntary contributions and signed consent form.
Exclusion criteria
Exclusion criteria: Pregnant women, prior to pregnancy or lactation The existence and history of conditions or serious wounds in the heart, lungs, kidney and other vital organs and the endocrine system. Also patients with respiratory and cancer disorders, tuberculosis and HIV infections. patients with chronic diarrhea or peptic ulcer up to one year patients suffering from malignancy or tumor patients with acute and chronic infectious diseases Patients with psychiatric disorders, alcohol and drug abuse Patients who refuse to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolic parameters [serum glucose and insulin levels, HOMA-IR and lipid profile (Triglyceride? Total cholesterol? LDL- cholesterol ? HDL- cholesterol)] in both study groups. Timepoint: Metabolic parameters measurement [serum glucose and insulin levels, HOMA-IR and lipid profile (Triglyceride? Total cholesterol? LDL- cholesterol ? HDL- cholesterol)] at baseline and 8 weeks (end of study) in both study groups. Method of measurement: Calorimetric methods (ELISA, spectrophotometry, autoanalyzer).;Systolic and diastolic blood pressure and anthropometric indices (weight, Body Mass Index, waist circumference, hip circumference and Waist to Hip Ratio) in both study groups. Timepoint: Measurement of systolic and diastolic blood pressure and anthropometric indices (weight, Body Mass Index, waist circumference, hip circumference and Waist to Hip Ratio) at baseline and 8 weeks (end of study) in both study groups. Method of measurement: A mercury barometer will be used to measure systolic and diastolic blood pressure, and digital scales, gauges and tape meters will be used for anthropometric measurements.;Levels of inflammatory biomarkers (Lipopolysaccharide and high sensitivity -CRP) in both study groups. Timepoint: Measurement of levels of inflammatory markers (Lipopolysaccharide and high sensitivity -CRP) at baseline and 8 weeks later (end of study) in both study groups. Method of measurement: Calorimetric methods (ELISA, spectrophotometry, autoanalyzer).;Levels of oxidative indices (Total Antioxidant Capacity and Malondialdehyde) in both study groups. Timepoint: Measurement of oxidative index levels (Total Antioxidant Capacity and Malondialdehyde) at baseline and 8 weeks (end of study) in both study groups. Method of measurement: Calorimetric methods (ELISA, spectrophotometry, autoanalyzer).;Clinical parameters (Health related quality of life questionnaire or SF-36, PASI or Psoriasis area and severity index and BDI-II or Beck Depression Inventory 2) in both study gro | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzizeh Farshbaf-khalili
Tabriz University of Medical Sciences
Outcome results
None listed